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The most prevalent symptoms were GI ones, but they also reported more unusual ones, such as irregular periods

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Using a continuous glucose monitor (CGM) device with alarm function and the possibility of remote monitoring of CGM data would also help mitigate hypoglycemic events in this context. Discontinuation As mentioned, the news is not all perfectly rosy, as Reasons for Discontinuation of Obesity Pharmacotherapy With Semaglutide or Tirzepatide in Clinical Practice shows

Modified-release (MR) preparations are an option when standard metformin causes gastrointestinal side effects